Sucrolse
Posted: Sun Jul 27, 2025 4:17 am
INS 955 - What is Sucralose? (Full Breakdown)
1. What is Sucralose?
Sucralose (INS 955) is a zero-calorie artificial sweetener, about 600x sweeter than sugar. It’s made by modifying regular sugar molecules and replacing 3 OH groups with chlorine atoms.
Chemical Name: 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside
Properties: Water-soluble, stable, non-fermentable
Taste: 600x sweeter than sugar, without bitterness
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2. Metabolism and Digestion
3. Regulatory Approvals
Sucralose has been approved worldwide for use in foods:
4. Safety and Toxicological Studies
5. Heat Concerns
6. Health Effects – Pros & Cons
Pros:
Cons (Mainly in high-dose animal studies):
7. Commercial Use
Sucralose is used in:
1. What is Sucralose?Sucralose (INS 955) is a zero-calorie artificial sweetener, about 600x sweeter than sugar. It’s made by modifying regular sugar molecules and replacing 3 OH groups with chlorine atoms.
Chemical Name: 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside
Properties: Water-soluble, stable, non-fermentable
Taste: 600x sweeter than sugar, without bitterness---
2. Metabolism and Digestion
- Around 85% of sucralose is not absorbed and is excreted unchanged.
- About 15% may be absorbed but is not metabolized—also excreted.
- Does NOT affect blood sugar, insulin, or calories.
3. Regulatory ApprovalsSucralose has been approved worldwide for use in foods:
FDA (USA) – Approved since 1998
EFSA (Europe) – ADI: 15 mg/kg/day
WHO/JECFA – Acceptable as safe
KKM (Malaysia) – Approved under INS 955
4. Safety and Toxicological Studies
- No cancer risk in long-term animal studies
- No effects on fertility or development
- No neurotoxicity even at high doses
- Recent rodent studies suggest possible gut microbiome changes, but human evidence is weak
5. Heat Concerns
- Sucralose can degrade when heated above 120°C (248°F)
- May form chlorinated byproducts like 3-MCPD, dioxins
- EFSA & German BfR advise not to use in baking or frying
- Safe in drinks, tea, and room temp use
6. Health Effects – Pros & Cons- Zero calorie sweetening
- Safe for diabetics – no insulin spike
- No tooth decay
- May affect gut microbiota
- Shouldn’t be heated too high
- Rare digestive discomfort in sensitive individuals
7. Commercial UseSucralose is used in:
- Soft drinks (sugar-free)
- Protein shakes and diet bars
- Yogurt and sugar-free desserts
- Table sweeteners (e.g. Splenda)
8. Jadual Ringkasan – Sucralose INS 955
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What Studies Say:
How to Support Your Gut While Using Sucralose:
Bottom Line: